Surgical treatment of pediatric intractable frontal lobe epilepsy due to malformation of cortical development

Abstract Background Malformation of cortical development (MCD) is a common cause intractable epilepsy in children. In this study, the effectiveness frontal lobe (FLE) surgery children with due to MCD was assessed and its prognostic factors were studied. Methods Seventy-six patients FLE who received between January 2016 March 2018 Peking University First Hospital recruited study. All resected brain tissues demonstrated be MCD. followed up for at least 3 years. The clinical data prognosis analyzed retrospectively. Univariate multivariate analyses performed investigate correlations variables outcome (Engel classification). Results Sixty (78.9%) had Engel class I postoperative outcome. mean age 6.00 ± 4.24 Sixty-six (86.8%) daily seizures, 40.2% epileptic spasm, 33% extensive interictal EEG abnormalities, which, however, could not provide any helpful information localizing epileptogenic zones. About 29% normal MRI findings even by experienced radiologists, 26% lesion involving adjacent lobes. There significant correlation acute seizure (APOS) ( P < 0.05): APOS predicted poor prognosis. pathology FCD IA IIB correlated good Both significance level 0.05 during univariate analysis, including APOS, included which independent predictors Conclusions manifestations pediatric are more complicated than those adults. Multidisplinary presurgical evaluation mandatory. surgical reach seizure-free rate 78.9% follow-up post-operative may related group patients.